GrippeEspagneV1, Main, Exploration, bibRecord, 000525

Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain.

Identifieur interne : 000525 ( Main/Exploration ); précédent : 000524; suivant : 000526

Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain.

Auteurs : Jordi Rello [Espagne] ; Alejandro Rodríguez ; Pedro Iba Ez ; Lorenzo Socias ; Javier Cebrian ; Asunci N Marques ; José Guerrero ; Sergio Ruiz-Santana ; Enrique Marquez ; Frutos Del Nogal-Saez ; Francisco Alvarez-Lerma ; Sergio Martínez ; Miquel Ferrer ; Manuel Avellanas ; Rosa Granada ; Enrique Maraví-Poma ; Patricia Albert ; Rafael Sierra ; Loreto Vidaur ; Patricia Ortiz ; Isidro Prieto Del Portillo ; Beatriz Galván ; Crist Bal Le N-Gil

Source :

Critical care (London, England) [ 1466-609X ] ; 2009.

RBID : pubmed:19747383

Descripteurs français

KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Antiviraux (administration et posologie), Antiviraux (pharmacologie), Audit médical (MeSH), Espagne (épidémiologie), Femelle (MeSH), Grippe humaine (complications), Grippe humaine (virologie), Grossesse (MeSH), Humains (MeSH), Indice de gravité de la maladie (MeSH), Insuffisance respiratoire (mortalité), Insuffisance respiratoire (physiopathologie), Insuffisance respiratoire (traitement médicamenteux), Insuffisance respiratoire (étiologie), Mutation (MeSH), Mâle (MeSH), Oséltamivir (administration et posologie), Oséltamivir (pharmacologie), RT-PCR (MeSH), Soins de réanimation (MeSH), Sous-type H1N1 du virus de la grippe A (génétique).
MESH :
- administration et posologie : Antiviraux, Oséltamivir.
- génétique : Sous-type H1N1 du virus de la grippe A.
- mortalité : Insuffisance respiratoire.
- pharmacologie : Antiviraux, Grippe humaine, Oséltamivir.
- physiopathologie : Insuffisance respiratoire.
- traitement médicamenteux : Insuffisance respiratoire.
- virologie : Grippe humaine.
- épidémiologie : Espagne.
- étiologie : Insuffisance respiratoire.
- Adulte, Adulte d'âge moyen, Audit médical, Femelle, Grossesse, Humains, Indice de gravité de la maladie, Mutation, Mâle, RT-PCR, Soins de réanimation.
Wicri :
- geographic : Espagne.

English descriptors

KwdEn :
- Adult (MeSH), Antiviral Agents (administration & dosage), Antiviral Agents (pharmacology), Critical Care (MeSH), Female (MeSH), Humans (MeSH), Influenza A Virus, H1N1 Subtype (genetics), Influenza, Human (complications), Influenza, Human (virology), Male (MeSH), Medical Audit (MeSH), Middle Aged (MeSH), Mutation (MeSH), Oseltamivir (administration & dosage), Oseltamivir (pharmacology), Pregnancy (MeSH), Respiratory Insufficiency (drug therapy), Respiratory Insufficiency (etiology), Respiratory Insufficiency (mortality), Respiratory Insufficiency (physiopathology), Reverse Transcriptase Polymerase Chain Reaction (MeSH), Severity of Illness Index (MeSH), Spain (epidemiology).
MESH :
- chemical , administration & dosage : Antiviral Agents, Oseltamivir.
- chemical , pharmacology : Antiviral Agents, Oseltamivir.
- geographic , epidemiology : Spain.
- complications : Influenza, Human.
- drug therapy : Respiratory Insufficiency.
- etiology : Respiratory Insufficiency.
- genetics : Influenza A Virus, H1N1 Subtype.
- mortality : Respiratory Insufficiency.
- physiopathology : Respiratory Insufficiency.
- virology : Influenza, Human.
- Adult, Critical Care, Female, Humans, Male, Medical Audit, Middle Aged, Mutation, Pregnancy, Reverse Transcriptase Polymerase Chain Reaction, Severity of Illness Index.

Abstract

INTRODUCTION

Patients with influenza A (H1N1)v infection have developed rapidly progressive lower respiratory tract disease resulting in respiratory failure. We describe the clinical and epidemiologic characteristics of the first 32 persons reported to be admitted to the intensive care unit (ICU) due to influenza A (H1N1)v infection in Spain.

METHODS

We used medical chart reviews to collect data on ICU adult patients reported in a standardized form. Influenza A (H1N1)v infection was confirmed in specimens using real-time reverse transcriptase-polymerase-chain-reaction (RT PCR) assay.

RESULTS

Illness onset of the 32 patients occurred between 23 June and 31 July, 2009. The median age was 36 years (IQR = 31 - 52). Ten (31.2%) were obese, 2 (6.3%) pregnant and 16 (50%) had pre-existing medical complications. Twenty-nine (90.6%) had primary viral pneumonitis, 2 (6.3%) exacerbation of structural respiratory disease and 1 (3.1%) secondary bacterial pneumonia. Twenty-four patients (75.0%) developed multiorgan dysfunction, 7 (21.9%) received renal replacement techniques and 24 (75.0%) required mechanical ventilation. Six patients died within 28 days, with two additional late deaths. Oseltamivir administration delay ranged from 2 to 8 days after illness onset, 31.2% received high-dose (300 mg/day), and treatment duration ranged from 5 to 10 days (mean 8.0 +/- 3.3).

CONCLUSIONS

Over a 5-week period, influenza A (H1N1)v infection led to ICU admission in 32 adult patients, with frequently observed severe hypoxemia and a relatively high case-fatality rate. Clinicians should be aware of pulmonary complications of influenza A (H1N1)v infection, particularly in pregnant and young obese but previously healthy persons.

DOI: 10.1186/cc8044
PubMed: 19747383
PubMed Central: PMC2784367

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 00509
to stream Main, to step Curation: 000509

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain.</title>
<author><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name>
<affiliation wicri:level="2"><nlm:affiliation>Critical Care Department, Joan XXIII University Hospital, CIBERes Enfermedades Respiratorias, IISPV, Mallafre Guasch 4, 43007 Tarragona, Spain. jrello.hj23.ics@gencat.cat</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Critical Care Department, Joan XXIII University Hospital, CIBERes Enfermedades Respiratorias, IISPV, Mallafre Guasch 4, 43007 Tarragona</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Alejandro" sort="Rodriguez, Alejandro" uniqKey="Rodriguez A" first="Alejandro" last="Rodríguez">Alejandro Rodríguez</name>
</author>
<author><name sortKey="Iba Ez, Pedro" sort="Iba Ez, Pedro" uniqKey="Iba Ez P" first="Pedro" last="Iba Ez">Pedro Iba Ez</name>
</author>
<author><name sortKey="Socias, Lorenzo" sort="Socias, Lorenzo" uniqKey="Socias L" first="Lorenzo" last="Socias">Lorenzo Socias</name>
</author>
<author><name sortKey="Cebrian, Javier" sort="Cebrian, Javier" uniqKey="Cebrian J" first="Javier" last="Cebrian">Javier Cebrian</name>
</author>
<author><name sortKey="Marques, Asunci N" sort="Marques, Asunci N" uniqKey="Marques A" first="Asunci N" last="Marques">Asunci N Marques</name>
</author>
<author><name sortKey="Guerrero, Jose" sort="Guerrero, Jose" uniqKey="Guerrero J" first="José" last="Guerrero">José Guerrero</name>
</author>
<author><name sortKey="Ruiz Santana, Sergio" sort="Ruiz Santana, Sergio" uniqKey="Ruiz Santana S" first="Sergio" last="Ruiz-Santana">Sergio Ruiz-Santana</name>
</author>
<author><name sortKey="Marquez, Enrique" sort="Marquez, Enrique" uniqKey="Marquez E" first="Enrique" last="Marquez">Enrique Marquez</name>
</author>
<author><name sortKey="Del Nogal Saez, Frutos" sort="Del Nogal Saez, Frutos" uniqKey="Del Nogal Saez F" first="Frutos" last="Del Nogal-Saez">Frutos Del Nogal-Saez</name>
</author>
<author><name sortKey="Alvarez Lerma, Francisco" sort="Alvarez Lerma, Francisco" uniqKey="Alvarez Lerma F" first="Francisco" last="Alvarez-Lerma">Francisco Alvarez-Lerma</name>
</author>
<author><name sortKey="Martinez, Sergio" sort="Martinez, Sergio" uniqKey="Martinez S" first="Sergio" last="Martínez">Sergio Martínez</name>
</author>
<author><name sortKey="Ferrer, Miquel" sort="Ferrer, Miquel" uniqKey="Ferrer M" first="Miquel" last="Ferrer">Miquel Ferrer</name>
</author>
<author><name sortKey="Avellanas, Manuel" sort="Avellanas, Manuel" uniqKey="Avellanas M" first="Manuel" last="Avellanas">Manuel Avellanas</name>
</author>
<author><name sortKey="Granada, Rosa" sort="Granada, Rosa" uniqKey="Granada R" first="Rosa" last="Granada">Rosa Granada</name>
</author>
<author><name sortKey="Maravi Poma, Enrique" sort="Maravi Poma, Enrique" uniqKey="Maravi Poma E" first="Enrique" last="Maraví-Poma">Enrique Maraví-Poma</name>
</author>
<author><name sortKey="Albert, Patricia" sort="Albert, Patricia" uniqKey="Albert P" first="Patricia" last="Albert">Patricia Albert</name>
</author>
<author><name sortKey="Sierra, Rafael" sort="Sierra, Rafael" uniqKey="Sierra R" first="Rafael" last="Sierra">Rafael Sierra</name>
</author>
<author><name sortKey="Vidaur, Loreto" sort="Vidaur, Loreto" uniqKey="Vidaur L" first="Loreto" last="Vidaur">Loreto Vidaur</name>
</author>
<author><name sortKey="Ortiz, Patricia" sort="Ortiz, Patricia" uniqKey="Ortiz P" first="Patricia" last="Ortiz">Patricia Ortiz</name>
</author>
<author><name sortKey="Prieto Del Portillo, Isidro" sort="Prieto Del Portillo, Isidro" uniqKey="Prieto Del Portillo I" first="Isidro" last="Prieto Del Portillo">Isidro Prieto Del Portillo</name>
</author>
<author><name sortKey="Galvan, Beatriz" sort="Galvan, Beatriz" uniqKey="Galvan B" first="Beatriz" last="Galván">Beatriz Galván</name>
</author>
<author><name sortKey="Le N Gil, Crist Bal" sort="Le N Gil, Crist Bal" uniqKey="Le N Gil C" first="Crist Bal" last="Le N-Gil">Crist Bal Le N-Gil</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2009">2009</date>
<idno type="RBID">pubmed:19747383</idno>
<idno type="pmid">19747383</idno>
<idno type="doi">10.1186/cc8044</idno>
<idno type="pmc">PMC2784367</idno>
<idno type="wicri:Area/Main/Corpus">00509</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">00509</idno>
<idno type="wicri:Area/Main/Curation">000509</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000509</idno>
<idno type="wicri:Area/Main/Exploration">000509</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain.</title>
<author><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name>
<affiliation wicri:level="2"><nlm:affiliation>Critical Care Department, Joan XXIII University Hospital, CIBERes Enfermedades Respiratorias, IISPV, Mallafre Guasch 4, 43007 Tarragona, Spain. jrello.hj23.ics@gencat.cat</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Critical Care Department, Joan XXIII University Hospital, CIBERes Enfermedades Respiratorias, IISPV, Mallafre Guasch 4, 43007 Tarragona</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Alejandro" sort="Rodriguez, Alejandro" uniqKey="Rodriguez A" first="Alejandro" last="Rodríguez">Alejandro Rodríguez</name>
</author>
<author><name sortKey="Iba Ez, Pedro" sort="Iba Ez, Pedro" uniqKey="Iba Ez P" first="Pedro" last="Iba Ez">Pedro Iba Ez</name>
</author>
<author><name sortKey="Socias, Lorenzo" sort="Socias, Lorenzo" uniqKey="Socias L" first="Lorenzo" last="Socias">Lorenzo Socias</name>
</author>
<author><name sortKey="Cebrian, Javier" sort="Cebrian, Javier" uniqKey="Cebrian J" first="Javier" last="Cebrian">Javier Cebrian</name>
</author>
<author><name sortKey="Marques, Asunci N" sort="Marques, Asunci N" uniqKey="Marques A" first="Asunci N" last="Marques">Asunci N Marques</name>
</author>
<author><name sortKey="Guerrero, Jose" sort="Guerrero, Jose" uniqKey="Guerrero J" first="José" last="Guerrero">José Guerrero</name>
</author>
<author><name sortKey="Ruiz Santana, Sergio" sort="Ruiz Santana, Sergio" uniqKey="Ruiz Santana S" first="Sergio" last="Ruiz-Santana">Sergio Ruiz-Santana</name>
</author>
<author><name sortKey="Marquez, Enrique" sort="Marquez, Enrique" uniqKey="Marquez E" first="Enrique" last="Marquez">Enrique Marquez</name>
</author>
<author><name sortKey="Del Nogal Saez, Frutos" sort="Del Nogal Saez, Frutos" uniqKey="Del Nogal Saez F" first="Frutos" last="Del Nogal-Saez">Frutos Del Nogal-Saez</name>
</author>
<author><name sortKey="Alvarez Lerma, Francisco" sort="Alvarez Lerma, Francisco" uniqKey="Alvarez Lerma F" first="Francisco" last="Alvarez-Lerma">Francisco Alvarez-Lerma</name>
</author>
<author><name sortKey="Martinez, Sergio" sort="Martinez, Sergio" uniqKey="Martinez S" first="Sergio" last="Martínez">Sergio Martínez</name>
</author>
<author><name sortKey="Ferrer, Miquel" sort="Ferrer, Miquel" uniqKey="Ferrer M" first="Miquel" last="Ferrer">Miquel Ferrer</name>
</author>
<author><name sortKey="Avellanas, Manuel" sort="Avellanas, Manuel" uniqKey="Avellanas M" first="Manuel" last="Avellanas">Manuel Avellanas</name>
</author>
<author><name sortKey="Granada, Rosa" sort="Granada, Rosa" uniqKey="Granada R" first="Rosa" last="Granada">Rosa Granada</name>
</author>
<author><name sortKey="Maravi Poma, Enrique" sort="Maravi Poma, Enrique" uniqKey="Maravi Poma E" first="Enrique" last="Maraví-Poma">Enrique Maraví-Poma</name>
</author>
<author><name sortKey="Albert, Patricia" sort="Albert, Patricia" uniqKey="Albert P" first="Patricia" last="Albert">Patricia Albert</name>
</author>
<author><name sortKey="Sierra, Rafael" sort="Sierra, Rafael" uniqKey="Sierra R" first="Rafael" last="Sierra">Rafael Sierra</name>
</author>
<author><name sortKey="Vidaur, Loreto" sort="Vidaur, Loreto" uniqKey="Vidaur L" first="Loreto" last="Vidaur">Loreto Vidaur</name>
</author>
<author><name sortKey="Ortiz, Patricia" sort="Ortiz, Patricia" uniqKey="Ortiz P" first="Patricia" last="Ortiz">Patricia Ortiz</name>
</author>
<author><name sortKey="Prieto Del Portillo, Isidro" sort="Prieto Del Portillo, Isidro" uniqKey="Prieto Del Portillo I" first="Isidro" last="Prieto Del Portillo">Isidro Prieto Del Portillo</name>
</author>
<author><name sortKey="Galvan, Beatriz" sort="Galvan, Beatriz" uniqKey="Galvan B" first="Beatriz" last="Galván">Beatriz Galván</name>
</author>
<author><name sortKey="Le N Gil, Crist Bal" sort="Le N Gil, Crist Bal" uniqKey="Le N Gil C" first="Crist Bal" last="Le N-Gil">Crist Bal Le N-Gil</name>
</author>
</analytic>
<series><title level="j">Critical care (London, England)</title>
<idno type="eISSN">1466-609X</idno>
<imprint><date when="2009" type="published">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Antiviral Agents (administration & dosage)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Critical Care (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Influenza A Virus, H1N1 Subtype (genetics)</term>
<term>Influenza, Human (complications)</term>
<term>Influenza, Human (virology)</term>
<term>Male (MeSH)</term>
<term>Medical Audit (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Mutation (MeSH)</term>
<term>Oseltamivir (administration & dosage)</term>
<term>Oseltamivir (pharmacology)</term>
<term>Pregnancy (MeSH)</term>
<term>Respiratory Insufficiency (drug therapy)</term>
<term>Respiratory Insufficiency (etiology)</term>
<term>Respiratory Insufficiency (mortality)</term>
<term>Respiratory Insufficiency (physiopathology)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction (MeSH)</term>
<term>Severity of Illness Index (MeSH)</term>
<term>Spain (epidemiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Antiviraux (administration et posologie)</term>
<term>Antiviraux (pharmacologie)</term>
<term>Audit médical (MeSH)</term>
<term>Espagne (épidémiologie)</term>
<term>Femelle (MeSH)</term>
<term>Grippe humaine (complications)</term>
<term>Grippe humaine (virologie)</term>
<term>Grossesse (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
<term>Insuffisance respiratoire (mortalité)</term>
<term>Insuffisance respiratoire (physiopathologie)</term>
<term>Insuffisance respiratoire (traitement médicamenteux)</term>
<term>Insuffisance respiratoire (étiologie)</term>
<term>Mutation (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Oséltamivir (administration et posologie)</term>
<term>Oséltamivir (pharmacologie)</term>
<term>RT-PCR (MeSH)</term>
<term>Soins de réanimation (MeSH)</term>
<term>Sous-type H1N1 du virus de la grippe A (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiviral Agents</term>
<term>Oseltamivir</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Oseltamivir</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antiviraux</term>
<term>Oséltamivir</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Respiratory Insufficiency</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Respiratory Insufficiency</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Respiratory Insufficiency</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Insuffisance respiratoire</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term>
<term>Grippe humaine</term>
<term>Oséltamivir</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Insuffisance respiratoire</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Respiratory Insufficiency</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Insuffisance respiratoire</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Insuffisance respiratoire</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Critical Care</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Medical Audit</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Pregnancy</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Audit médical</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Indice de gravité de la maladie</term>
<term>Mutation</term>
<term>Mâle</term>
<term>RT-PCR</term>
<term>Soins de réanimation</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b>
</p>
<p>Patients with influenza A (H1N1)v infection have developed rapidly progressive lower respiratory tract disease resulting in respiratory failure. We describe the clinical and epidemiologic characteristics of the first 32 persons reported to be admitted to the intensive care unit (ICU) due to influenza A (H1N1)v infection in Spain.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We used medical chart reviews to collect data on ICU adult patients reported in a standardized form. Influenza A (H1N1)v infection was confirmed in specimens using real-time reverse transcriptase-polymerase-chain-reaction (RT PCR) assay.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Illness onset of the 32 patients occurred between 23 June and 31 July, 2009. The median age was 36 years (IQR = 31 - 52). Ten (31.2%) were obese, 2 (6.3%) pregnant and 16 (50%) had pre-existing medical complications. Twenty-nine (90.6%) had primary viral pneumonitis, 2 (6.3%) exacerbation of structural respiratory disease and 1 (3.1%) secondary bacterial pneumonia. Twenty-four patients (75.0%) developed multiorgan dysfunction, 7 (21.9%) received renal replacement techniques and 24 (75.0%) required mechanical ventilation. Six patients died within 28 days, with two additional late deaths. Oseltamivir administration delay ranged from 2 to 8 days after illness onset, 31.2% received high-dose (300 mg/day), and treatment duration ranged from 5 to 10 days (mean 8.0 +/- 3.3).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Over a 5-week period, influenza A (H1N1)v infection led to ICU admission in 32 adult patients, with frequently observed severe hypoxemia and a relatively high case-fatality rate. Clinicians should be aware of pulmonary complications of influenza A (H1N1)v infection, particularly in pregnant and young obese but previously healthy persons.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19747383</PMID>
<DateCompleted><Year>2010</Year>
<Month>03</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1466-609X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>13</Volume>
<Issue>5</Issue>
<PubDate><Year>2009</Year>
</PubDate>
</JournalIssue>
<Title>Critical care (London, England)</Title>
<ISOAbbreviation>Crit Care</ISOAbbreviation>
</Journal>
<ArticleTitle>Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain.</ArticleTitle>
<Pagination><MedlinePgn>R148</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/cc8044</ELocationID>
<Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Patients with influenza A (H1N1)v infection have developed rapidly progressive lower respiratory tract disease resulting in respiratory failure. We describe the clinical and epidemiologic characteristics of the first 32 persons reported to be admitted to the intensive care unit (ICU) due to influenza A (H1N1)v infection in Spain.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We used medical chart reviews to collect data on ICU adult patients reported in a standardized form. Influenza A (H1N1)v infection was confirmed in specimens using real-time reverse transcriptase-polymerase-chain-reaction (RT PCR) assay.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Illness onset of the 32 patients occurred between 23 June and 31 July, 2009. The median age was 36 years (IQR = 31 - 52). Ten (31.2%) were obese, 2 (6.3%) pregnant and 16 (50%) had pre-existing medical complications. Twenty-nine (90.6%) had primary viral pneumonitis, 2 (6.3%) exacerbation of structural respiratory disease and 1 (3.1%) secondary bacterial pneumonia. Twenty-four patients (75.0%) developed multiorgan dysfunction, 7 (21.9%) received renal replacement techniques and 24 (75.0%) required mechanical ventilation. Six patients died within 28 days, with two additional late deaths. Oseltamivir administration delay ranged from 2 to 8 days after illness onset, 31.2% received high-dose (300 mg/day), and treatment duration ranged from 5 to 10 days (mean 8.0 +/- 3.3).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Over a 5-week period, influenza A (H1N1)v infection led to ICU admission in 32 adult patients, with frequently observed severe hypoxemia and a relatively high case-fatality rate. Clinicians should be aware of pulmonary complications of influenza A (H1N1)v infection, particularly in pregnant and young obese but previously healthy persons.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rello</LastName>
<ForeName>Jordi</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Critical Care Department, Joan XXIII University Hospital, CIBERes Enfermedades Respiratorias, IISPV, Mallafre Guasch 4, 43007 Tarragona, Spain. jrello.hj23.ics@gencat.cat</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rodríguez</LastName>
<ForeName>Alejandro</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ibañez</LastName>
<ForeName>Pedro</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><LastName>Socias</LastName>
<ForeName>Lorenzo</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Cebrian</LastName>
<ForeName>Javier</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Marques</LastName>
<ForeName>Asunción</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Guerrero</LastName>
<ForeName>José</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ruiz-Santana</LastName>
<ForeName>Sergio</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Marquez</LastName>
<ForeName>Enrique</ForeName>
<Initials>E</Initials>
</Author>
<Author ValidYN="Y"><LastName>Del Nogal-Saez</LastName>
<ForeName>Frutos</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y"><LastName>Alvarez-Lerma</LastName>
<ForeName>Francisco</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y"><LastName>Martínez</LastName>
<ForeName>Sergio</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ferrer</LastName>
<ForeName>Miquel</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Avellanas</LastName>
<ForeName>Manuel</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Granada</LastName>
<ForeName>Rosa</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Maraví-Poma</LastName>
<ForeName>Enrique</ForeName>
<Initials>E</Initials>
</Author>
<Author ValidYN="Y"><LastName>Albert</LastName>
<ForeName>Patricia</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sierra</LastName>
<ForeName>Rafael</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Vidaur</LastName>
<ForeName>Loreto</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ortiz</LastName>
<ForeName>Patricia</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><LastName>Prieto del Portillo</LastName>
<ForeName>Isidro</ForeName>
<Initials>I</Initials>
</Author>
<Author ValidYN="Y"><LastName>Galván</LastName>
<ForeName>Beatriz</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>León-Gil</LastName>
<ForeName>Cristóbal</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><CollectiveName>H1N1 SEMICYUC Working Group</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2009</Year>
<Month>09</Month>
<Day>11</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Crit Care</MedlineTA>
<NlmUniqueID>9801902</NlmUniqueID>
<ISSNLinking>1364-8535</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>20O93L6F9H</RegistryNumber>
<NameOfSubstance UI="D053139">Oseltamivir</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Crit Care. 2009;13(5):196</RefSource>
<PMID Version="1">19863761</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>Crit Care. 2009;13(6):426; author reply 426</RefSource>
<PMID Version="1">19954506</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>Crit Care. 2009;13(6):425; author reply 425</RefSource>
<PMID Version="1">19954507</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>Crit Care. 2009;13(6):428; author reply 428</RefSource>
<PMID Version="1">20067602</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>Crit Care. 2010;14(2):407</RefSource>
<PMID Version="1">20346097</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003422" MajorTopicYN="Y">Critical Care</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008485" MajorTopicYN="N">Medical Audit</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053139" MajorTopicYN="N">Oseltamivir</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012131" MajorTopicYN="N">Respiratory Insufficiency</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="Y">Severity of Illness Index</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<InvestigatorList><Investigator ValidYN="Y"><LastName>Lisboa</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>de Mendoza</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Borges-Sa</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Socias</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Torres</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ballus Noguera</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Blasco Navalpotro</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jiménez Urra</LastName>
<ForeName>I</ForeName>
<Initials>I</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Macaya Redín</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Tellería</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Garrido Ramírez de Arellano</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Marquina Lacueva</LastName>
<ForeName>M I</ForeName>
<Initials>MI</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Zaragoza</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Liétor</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ramos</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fugueira</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cruz Soriano</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sánchez-Morcillo</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Tormo</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Marco</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>González</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Garnacho-Montero</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Alvarez-Rocha</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bonet</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sirvent</LastName>
<ForeName>J M</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>López de Arbina</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Barcenilla</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Badia</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mariscal</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Vaquero</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>García</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rodríguez</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Nolla</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hernández</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Vallés</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ortíz Hernández</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Guía</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pomarés</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Santamaria</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Loza</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Galdós</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hernández</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cobo Castellano</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lorente Ramos</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bonastre</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Palamo</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fernández</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ramón</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ortiz Piquer</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Blanco Peréz</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Balanzo</LastName>
<ForeName>X</ForeName>
<Initials>X</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Almirall</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Martín Velasco</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jordá Marcos</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sanchez Alonso</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cáceres</LastName>
<ForeName>J J</ForeName>
<Initials>JJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Castillo Arenal</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Carrasco</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pascual González</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Nava</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>González de Molina</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Díaz Lamas</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Martínez López</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rovira</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Guerrero</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Insausti</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>García López</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Díaz</LastName>
<ForeName>J J</ForeName>
<Initials>JJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Paez</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ugarte</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
</InvestigatorList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2009</Year>
<Month>08</Month>
<Day>06</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2009</Year>
<Month>08</Month>
<Day>25</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2009</Year>
<Month>09</Month>
<Day>11</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2009</Year>
<Month>9</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2009</Year>
<Month>9</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2010</Year>
<Month>3</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">19747383</ArticleId>
<ArticleId IdType="pii">cc8044</ArticleId>
<ArticleId IdType="doi">10.1186/cc8044</ArticleId>
<ArticleId IdType="pmc">PMC2784367</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Intensive Care Med. 1996 Jul;22(7):707-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8844239</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2009 Aug 8;374(9688):451-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19643469</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med J Aust. 2009 Aug 3;191(3):154-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19645645</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MMWR Morb Mortal Wkly Rep. 2009 Jul 17;58(27):749-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19609249</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MMWR Morb Mortal Wkly Rep. 2009 May 22;58(19):536-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19478723</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Tohoku J Exp Med. 2000 Sep;192(1):81-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11128871</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Crit Care. 2004 Aug;8(4):R204-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15312219</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Crit Care Med. 1985 Oct;13(10):818-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3928249</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2009 Aug 13;361(7):680-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19564631</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2007 Mar 1;44 Suppl 2:S27-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17278083</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2007 Dec 15;45(12):1568-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18190317</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2008 Jan 17;358(3):261-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18199865</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2009 Apr 15;48(8):1003-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19281331</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Catalogne</li>
</region>
</list>
<tree><noCountry><name sortKey="Albert, Patricia" sort="Albert, Patricia" uniqKey="Albert P" first="Patricia" last="Albert">Patricia Albert</name>
<name sortKey="Alvarez Lerma, Francisco" sort="Alvarez Lerma, Francisco" uniqKey="Alvarez Lerma F" first="Francisco" last="Alvarez-Lerma">Francisco Alvarez-Lerma</name>
<name sortKey="Avellanas, Manuel" sort="Avellanas, Manuel" uniqKey="Avellanas M" first="Manuel" last="Avellanas">Manuel Avellanas</name>
<name sortKey="Cebrian, Javier" sort="Cebrian, Javier" uniqKey="Cebrian J" first="Javier" last="Cebrian">Javier Cebrian</name>
<name sortKey="Del Nogal Saez, Frutos" sort="Del Nogal Saez, Frutos" uniqKey="Del Nogal Saez F" first="Frutos" last="Del Nogal-Saez">Frutos Del Nogal-Saez</name>
<name sortKey="Ferrer, Miquel" sort="Ferrer, Miquel" uniqKey="Ferrer M" first="Miquel" last="Ferrer">Miquel Ferrer</name>
<name sortKey="Galvan, Beatriz" sort="Galvan, Beatriz" uniqKey="Galvan B" first="Beatriz" last="Galván">Beatriz Galván</name>
<name sortKey="Granada, Rosa" sort="Granada, Rosa" uniqKey="Granada R" first="Rosa" last="Granada">Rosa Granada</name>
<name sortKey="Guerrero, Jose" sort="Guerrero, Jose" uniqKey="Guerrero J" first="José" last="Guerrero">José Guerrero</name>
<name sortKey="Iba Ez, Pedro" sort="Iba Ez, Pedro" uniqKey="Iba Ez P" first="Pedro" last="Iba Ez">Pedro Iba Ez</name>
<name sortKey="Le N Gil, Crist Bal" sort="Le N Gil, Crist Bal" uniqKey="Le N Gil C" first="Crist Bal" last="Le N-Gil">Crist Bal Le N-Gil</name>
<name sortKey="Maravi Poma, Enrique" sort="Maravi Poma, Enrique" uniqKey="Maravi Poma E" first="Enrique" last="Maraví-Poma">Enrique Maraví-Poma</name>
<name sortKey="Marques, Asunci N" sort="Marques, Asunci N" uniqKey="Marques A" first="Asunci N" last="Marques">Asunci N Marques</name>
<name sortKey="Marquez, Enrique" sort="Marquez, Enrique" uniqKey="Marquez E" first="Enrique" last="Marquez">Enrique Marquez</name>
<name sortKey="Martinez, Sergio" sort="Martinez, Sergio" uniqKey="Martinez S" first="Sergio" last="Martínez">Sergio Martínez</name>
<name sortKey="Ortiz, Patricia" sort="Ortiz, Patricia" uniqKey="Ortiz P" first="Patricia" last="Ortiz">Patricia Ortiz</name>
<name sortKey="Prieto Del Portillo, Isidro" sort="Prieto Del Portillo, Isidro" uniqKey="Prieto Del Portillo I" first="Isidro" last="Prieto Del Portillo">Isidro Prieto Del Portillo</name>
<name sortKey="Rodriguez, Alejandro" sort="Rodriguez, Alejandro" uniqKey="Rodriguez A" first="Alejandro" last="Rodríguez">Alejandro Rodríguez</name>
<name sortKey="Ruiz Santana, Sergio" sort="Ruiz Santana, Sergio" uniqKey="Ruiz Santana S" first="Sergio" last="Ruiz-Santana">Sergio Ruiz-Santana</name>
<name sortKey="Sierra, Rafael" sort="Sierra, Rafael" uniqKey="Sierra R" first="Rafael" last="Sierra">Rafael Sierra</name>
<name sortKey="Socias, Lorenzo" sort="Socias, Lorenzo" uniqKey="Socias L" first="Lorenzo" last="Socias">Lorenzo Socias</name>
<name sortKey="Vidaur, Loreto" sort="Vidaur, Loreto" uniqKey="Vidaur L" first="Loreto" last="Vidaur">Loreto Vidaur</name>
</noCountry>
<country name="Espagne"><region name="Catalogne"><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/GrippeEspagneV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000525 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000525 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    GrippeEspagneV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:19747383
   |texte=   Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:19747383" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a GrippeEspagneV1

This area was generated with Dilib version V0.6.37.
Data generation: Fri Sep 25 11:01:38 2020. Site generation: Sat Feb 13 17:38:04 2021

	Serveur d'exploration sur la grippe en Espagne
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la grippe en Espagne

Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain.

Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki